diff --git a/src/slic3r/GUI/Widgets/ComboBox.cpp b/src/slic3r/GUI/Widgets/ComboBox.cpp
index 26969b1ceb..cfc61c744c 100644
--- a/src/slic3r/GUI/Widgets/ComboBox.cpp
+++ b/src/slic3r/GUI/Widgets/ComboBox.cpp
@@ -278,6 +278,8 @@ void ComboBox::DoSetItemClientData(unsigned int n, void *data)
 
 void ComboBox::mouseDown(wxMouseEvent &event)
 {
+    if (!IsEnabled()) { return; } /*on mac, the event may triggered even disabled*/
+
     SetFocus();
     if (drop_down) {
         drop.Hide();