diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index 3182d93e92..074cfe0dcb 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -854,8 +854,6 @@ static_assert(COUNT(arm) == LOGICAL_AXES, "AXIS_RELATIVE_MODES must contain " _L
   #if ENABLED(SMOOTH_LIN_ADVANCE)
     #ifndef CPU_32_BIT
       #error "SMOOTH_LIN_ADVANCE requires a 32-bit CPU."
-    #elif DISTINCT_E > 1
-      #error "SMOOTH_LIN_ADVANCE is not compatible with multiple extruders."
     #elif ENABLED(S_CURVE_ACCELERATION)
       #error "SMOOTH_LIN_ADVANCE is not compatible with S_CURVE_ACCELERATION."
     #elif ENABLED(INPUT_SHAPING_E_SYNC) && NONE(INPUT_SHAPING_X, INPUT_SHAPING_Y)