diff --git a/cura/Settings/MachineManager.py b/cura/Settings/MachineManager.py
index 7511fcd109..4bdcc022df 100755
--- a/cura/Settings/MachineManager.py
+++ b/cura/Settings/MachineManager.py
@@ -1438,6 +1438,8 @@ class MachineManager(QObject):
                     self._global_container_stack.extruders[position].setEnabled(True)
                     self.updateMaterialWithVariant(position)
 
+            self.updateNumberExtrudersEnabled()
+
             if configuration.buildplateConfiguration is not None:
                 global_variant_container_node = self._variant_manager.getBuildplateVariantNode(self._global_container_stack.definition.getId(), configuration.buildplateConfiguration)
                 if global_variant_container_node: