diff --git a/cura/Settings/MachineManager.py b/cura/Settings/MachineManager.py
index 3a6015e90f..50c3c53734 100755
--- a/cura/Settings/MachineManager.py
+++ b/cura/Settings/MachineManager.py
@@ -145,6 +145,7 @@ class MachineManager(QObject):
     activeStackValueChanged = pyqtSignal()  # Emitted whenever a value inside the active stack is changed.
     activeStackValidationChanged = pyqtSignal()  # Emitted whenever a validation inside active container is changed
     stacksValidationChanged = pyqtSignal()  # Emitted whenever a validation is changed
+    numberExtrudersEnabledChanged = pyqtSignal()  # Emitted when the number of extruders that are enabled changed
 
     blurSettings = pyqtSignal()  # Emitted to force fields in the advanced sidebar to un-focus, so they update properly
 
@@ -880,7 +881,13 @@ class MachineManager(QObject):
         for position, extruder in self._global_container_stack.extruders.items():
             if extruder.isEnabled:
                 extruder_count += 1
-        definition_changes_container.setProperty("extruders_enabled_count", "value", extruder_count)
+        if self.numberExtrudersEnabled != extruder_count:
+            definition_changes_container.setProperty("extruders_enabled_count", "value", extruder_count)
+            self.numberExtrudersEnabledChanged.emit()
+
+    @pyqtProperty(int, notify = numberExtrudersEnabledChanged)
+    def numberExtrudersEnabled(self):
+        return self._global_container_stack.definitionChanges.getProperty("extruders_enabled_count", "value")
 
     @pyqtProperty(str, notify = extruderChanged)
     def defaultExtruderPosition(self):
diff --git a/resources/qml/Cura.qml b/resources/qml/Cura.qml
index cff4399073..c4ebb790e8 100644
--- a/resources/qml/Cura.qml
+++ b/resources/qml/Cura.qml
@@ -217,6 +217,7 @@ UM.MainWindow
                             text: catalog.i18nc("@action:inmenu", "Disable Extruder")
                             onTriggered: Cura.MachineManager.setExtruderEnabled(model.index, false)
                             visible: Cura.MachineManager.getExtruder(model.index).isEnabled
+                            enabled: Cura.MachineManager.numberExtrudersEnabled > 1
                         }
 
                     }
diff --git a/resources/qml/SidebarHeader.qml b/resources/qml/SidebarHeader.qml
index 5cd0446b36..92af6e9cc9 100644
--- a/resources/qml/SidebarHeader.qml
+++ b/resources/qml/SidebarHeader.qml
@@ -178,6 +178,7 @@ Column
                         text: catalog.i18nc("@action:inmenu", "Disable Extruder")
                         onTriggered: Cura.MachineManager.setExtruderEnabled(model.index, false)
                         visible: extruder_enabled
+                        enabled: Cura.MachineManager.numberExtrudersEnabled > 1
                     }
                 }