diff --git a/cura/Settings/ProfilesModel.py b/cura/Settings/ProfilesModel.py
index fb3e107ee6..bf1993b184 100644
--- a/cura/Settings/ProfilesModel.py
+++ b/cura/Settings/ProfilesModel.py
@@ -100,6 +100,9 @@ class ProfilesModel(InstanceContainersModel):
         extruder_stacks = extruder_manager.getActiveExtruderStacks()
         if multiple_extrusion:
             # Place the active extruder at the front of the list.
+            # This is a workaround checking if there is an active_extruder or not before moving it to the front of the list.
+            # Actually, when a printer has multiple extruders, should exist always an active_extruder. However, in some
+            # cases the active_extruder is still None.
             if active_extruder in extruder_stacks:
                 extruder_stacks.remove(active_extruder)
             new_extruder_stacks = []
diff --git a/cura/Settings/QualityAndUserProfilesModel.py b/cura/Settings/QualityAndUserProfilesModel.py
index 51b4c1bb1a..f2728aff14 100644
--- a/cura/Settings/QualityAndUserProfilesModel.py
+++ b/cura/Settings/QualityAndUserProfilesModel.py
@@ -33,8 +33,15 @@ class QualityAndUserProfilesModel(ProfilesModel):
         extruder_stacks = extruder_manager.getActiveExtruderStacks()
         if multiple_extrusion:
             # Place the active extruder at the front of the list.
-            extruder_stacks.remove(active_extruder)
-            extruder_stacks = [active_extruder] + extruder_stacks
+            # This is a workaround checking if there is an active_extruder or not before moving it to the front of the list.
+            # Actually, when a printer has multiple extruders, should exist always an active_extruder. However, in some
+            # cases the active_extruder is still None.
+            if active_extruder in extruder_stacks:
+                extruder_stacks.remove(active_extruder)
+            new_extruder_stacks = []
+            if active_extruder is not None:
+                new_extruder_stacks = [active_extruder]
+            extruder_stacks = new_extruder_stacks + extruder_stacks
 
         # Fetch the list of useable qualities across all extruders.
         # The actual list of quality profiles come from the first extruder in the extruder list.
diff --git a/cura/Settings/UserProfilesModel.py b/cura/Settings/UserProfilesModel.py
index 223900306b..587e27f359 100644
--- a/cura/Settings/UserProfilesModel.py
+++ b/cura/Settings/UserProfilesModel.py
@@ -33,6 +33,9 @@ class UserProfilesModel(ProfilesModel):
         extruder_stacks = extruder_manager.getActiveExtruderStacks()
         if multiple_extrusion:
             # Place the active extruder at the front of the list.
+            # This is a workaround checking if there is an active_extruder or not before moving it to the front of the list.
+            # Actually, when a printer has multiple extruders, should exist always an active_extruder. However, in some
+            # cases the active_extruder is still None.
             if active_extruder in extruder_stacks:
                 extruder_stacks.remove(active_extruder)
             new_extruder_stacks = []