diff --git a/cura/CuraApplication.py b/cura/CuraApplication.py
index e5c0c5688c..0de5066d8b 100755
--- a/cura/CuraApplication.py
+++ b/cura/CuraApplication.py
@@ -1701,3 +1701,22 @@ class CuraApplication(QtApplication):
     @pyqtSlot()
     def showMoreInformationDialogForAnonymousDataCollection(self):
         cast(SliceInfo, self._plugin_registry.getPluginObject("SliceInfoPlugin")).showMoreInfoDialog()
+
+    ##  Signal to check whether the application can be closed or not
+    checkCuraCloseChange = pyqtSignal()
+
+    # This variable is necessary to ensure that all methods that were subscribed for the checkCuraCloseChange event
+    # have been passed checks
+    _isCuraCanBeClosed = True
+
+    def setCuraCanBeClosed(self, value: bool):
+        self._isCuraCanBeClosed = value
+
+    @pyqtSlot(result=bool)
+    def preCloseEventHandler(self)-> bool:
+
+        # If any of checks failed then then _isCuraCanBeClosed should be set to False and Cura will not be closed
+        # after clicking the quit button
+        self.checkCuraCloseChange.emit()
+
+        return self._isCuraCanBeClosed
diff --git a/plugins/USBPrinting/USBPrinterOutputDevice.py b/plugins/USBPrinting/USBPrinterOutputDevice.py
index f9c6011f7b..fc9558056b 100644
--- a/plugins/USBPrinting/USBPrinterOutputDevice.py
+++ b/plugins/USBPrinting/USBPrinterOutputDevice.py
@@ -435,6 +435,9 @@ class USBPrinterOutputDevice(PrinterOutputDevice):
 
         self._gcode_position += 1
 
+    def getIsPrinting(self)-> bool:
+        return self._is_printing
+
 
 class FirmwareUpdateState(IntEnum):
     idle = 0
diff --git a/plugins/USBPrinting/USBPrinterOutputDeviceManager.py b/plugins/USBPrinting/USBPrinterOutputDeviceManager.py
index 2ee85187ee..b2dc24480c 100644
--- a/plugins/USBPrinting/USBPrinterOutputDeviceManager.py
+++ b/plugins/USBPrinting/USBPrinterOutputDeviceManager.py
@@ -6,7 +6,8 @@ import platform
 import time
 import serial.tools.list_ports
 
-from PyQt5.QtCore import QObject, pyqtSlot, pyqtProperty, pyqtSignal
+from PyQt5.QtCore import QObject, pyqtSlot, pyqtSignal, QCoreApplication
+from PyQt5.QtWidgets import QMessageBox
 
 from UM.Logger import Logger
 from UM.Resources import Resources
@@ -50,6 +51,11 @@ class USBPrinterOutputDeviceManager(QObject, OutputDevicePlugin):
 
         self._application.globalContainerStackChanged.connect(self.updateUSBPrinterOutputDevices)
 
+        self._application.checkCuraCloseChange.connect(self.checkWheterUSBIsActiveOrNot)
+
+        self._lock = threading.Lock()
+        self._confirm_dialog_visible = False
+
     # The method updates/reset the USB settings for all connected USB devices
     def updateUSBPrinterOutputDevices(self):
         for key, device in self._usb_output_devices.items():
@@ -184,3 +190,51 @@ class USBPrinterOutputDeviceManager(QObject, OutputDevicePlugin):
     @classmethod
     def getInstance(cls, *args, **kwargs) -> "USBPrinterOutputDeviceManager":
         return cls.__instance
+
+    # The method checks whether a printer is printing via USB or not before closing cura. If the printer is printing then pop up a
+    # dialog to confirm stop printing
+    def checkWheterUSBIsActiveOrNot(self)-> None:
+
+        is_printing = False
+        for key, device in self._usb_output_devices.items():
+            if type(device) is USBPrinterOutputDevice.USBPrinterOutputDevice:
+                if device.getIsPrinting():
+                    is_printing = True
+                    break
+
+        if is_printing:
+            if threading.current_thread() != threading.main_thread():
+                self._lock.acquire()
+            self._confirm_dialog_visible = True
+
+            CuraApplication.getInstance().messageBox(i18n_catalog.i18nc("@window:title", "Confirm stop printing"),
+                                                     i18n_catalog.i18nc("@window:message","A USB print is in progress, closing Cura will stop this print. Are you sure?"),
+                                                     buttons=QMessageBox.Yes + QMessageBox.No,
+                                                     icon=QMessageBox.Question,
+                                                     callback=self._messageBoxCallback)
+            # Wait for dialog result
+            self.waitForClose()
+
+    ##  Block thread until the dialog is closed.
+    def waitForClose(self)-> None:
+        if self._confirm_dialog_visible:
+            if threading.current_thread() != threading.main_thread():
+                self._lock.acquire()
+                self._lock.release()
+            else:
+                # If this is not run from a separate thread, we need to ensure that the events are still processed.
+                while self._confirm_dialog_visible:
+                    time.sleep(1 / 50)
+                    QCoreApplication.processEvents()  # Ensure that the GUI does not freeze.
+
+    def _messageBoxCallback(self, button):
+        if button == QMessageBox.Yes:
+            self._application.setCuraCanBeClosed(True)
+        else:
+            self._application.setCuraCanBeClosed(False)
+
+        self._confirm_dialog_visible = False
+        try:
+            self._lock.release()
+        except:
+            pass
\ No newline at end of file
diff --git a/resources/qml/Cura.qml b/resources/qml/Cura.qml
index 692a6fc259..20638e8850 100644
--- a/resources/qml/Cura.qml
+++ b/resources/qml/Cura.qml
@@ -22,6 +22,12 @@ UM.MainWindow
 
     backgroundColor: UM.Theme.getColor("viewport_background")
 
+    // Event which does the check before closing the window
+    onPreCloseChange:
+    {
+        event.accepted = CuraApplication.preCloseEventHandler()
+    }
+
     // This connection is here to support legacy printer output devices that use the showPrintMonitor signal on Application to switch to the monitor stage
     // It should be phased out in newer plugin versions.
     Connections