diff --git a/plugins/CuraEngineBackend/StartSliceJob.py b/plugins/CuraEngineBackend/StartSliceJob.py
index 8b27a0319a..8f312a4afb 100644
--- a/plugins/CuraEngineBackend/StartSliceJob.py
+++ b/plugins/CuraEngineBackend/StartSliceJob.py
@@ -415,11 +415,12 @@ class StartSliceJob(Job):
             for node in group:
                 # Only check if the printing extruder is enabled for printing meshes
                 is_non_printing_mesh = node.callDecoration("evaluateIsNonPrintingMesh")
-                extruder_position = int(node.callDecoration("getActiveExtruderPosition"))
-                if not is_non_printing_mesh and not extruders_enabled[extruder_position]:
-                    skip_group = True
-                    has_model_with_disabled_extruders = True
-                    associated_disabled_extruders.add(extruder_position)
+                if not is_non_printing_mesh:
+                    for used_extruder in StartSliceJob._getUsedExtruders(node):
+                        if not extruders_enabled[used_extruder]:
+                            skip_group = True
+                            has_model_with_disabled_extruders = True
+                            associated_disabled_extruders.add(used_extruder)
             if not skip_group:
                 filtered_object_groups.append(group)
 
@@ -760,3 +761,27 @@ class StartSliceJob(Job):
 
             relations_set.add(relation.target.key)
             self._addRelations(relations_set, relation.target.relations)
+
+    @staticmethod
+    def _getUsedExtruders(node: SceneNode) -> List[int]:
+        used_extruders = []
+
+        # Look at extruders used in painted texture
+        node_texture = node.callDecoration("getPaintTexture")
+        texture_data_mapping = node.callDecoration("getTextureDataMapping")
+        if node_texture is not None and texture_data_mapping is not None and "extruder" in texture_data_mapping:
+            texture_image = node_texture.getImage().copy()
+            image_ptr = texture_image.bits()
+            image_ptr.setsize(texture_image.sizeInBytes())
+            image_size = texture_image.height(), texture_image.width()
+            image_array = numpy.frombuffer(image_ptr, dtype=numpy.uint32).reshape(image_size)
+
+            bit_range_start, bit_range_end = texture_data_mapping["extruder"]
+            image_array = (image_array << (32 - 1 - (bit_range_end - bit_range_start))) >> (32 - 1 - bit_range_end)
+            used_extruders = numpy.unique(image_array).tolist()
+
+        # There is no relevant painting data, just take the extruder associated to the model
+        if not used_extruders:
+            used_extruders = [int(node.callDecoration("getActiveExtruderPosition"))]
+
+        return used_extruders
\ No newline at end of file