diff --git a/plugins/CuraEngineBackend/CuraEngineBackend.py b/plugins/CuraEngineBackend/CuraEngineBackend.py
index d298ff1aca..3e66edc203 100755
--- a/plugins/CuraEngineBackend/CuraEngineBackend.py
+++ b/plugins/CuraEngineBackend/CuraEngineBackend.py
@@ -379,6 +379,14 @@ class CuraEngineBackend(QObject, Backend):
             else:
                 self.backendStateChange.emit(BackendState.NotStarted)
 
+        if job.getResult() == StartSliceJob.StartJobResult.ObjectsWithDisabledExtruder:
+            self._error_message = Message(catalog.i18nc("@info:status", "Unable to slice because there are objects associated with disabled Extruder %s." % job.getMessage()),
+                                          title = catalog.i18nc("@info:title", "Unable to slice"))
+            self._error_message.show()
+            self.backendStateChange.emit(BackendState.Error)
+            self.backendError.emit(job)
+            return
+
         if job.getResult() == StartSliceJob.StartJobResult.NothingToSlice:
             if Application.getInstance().platformActivity:
                 self._error_message = Message(catalog.i18nc("@info:status", "Nothing to slice because none of the models fit the build volume. Please scale or rotate models to fit."),
diff --git a/plugins/CuraEngineBackend/StartSliceJob.py b/plugins/CuraEngineBackend/StartSliceJob.py
index 467351dd4b..b704ca0d2f 100644
--- a/plugins/CuraEngineBackend/StartSliceJob.py
+++ b/plugins/CuraEngineBackend/StartSliceJob.py
@@ -32,6 +32,7 @@ class StartJobResult(IntEnum):
     MaterialIncompatible = 5
     BuildPlateError = 6
     ObjectSettingError = 7 #When an error occurs in per-object settings.
+    ObjectsWithDisabledExtruder = 8
 
 
 ##  Formatter class that handles token expansion in start/end gcod
@@ -213,16 +214,27 @@ class StartSliceJob(Job):
 
             extruders_enabled = {position: stack.isEnabled for position, stack in Application.getInstance().getGlobalContainerStack().extruders.items()}
             filtered_object_groups = []
+            has_model_with_disabled_extruders = False
+            associated_siabled_extruders = set()
             for group in object_groups:
                 stack = Application.getInstance().getGlobalContainerStack()
                 skip_group = False
                 for node in group:
-                    if not extruders_enabled[node.callDecoration("getActiveExtruderPosition")]:
+                    extruder_position = node.callDecoration("getActiveExtruderPosition")
+                    if not extruders_enabled[extruder_position]:
                         skip_group = True
+                        has_model_with_disabled_extruders = True
+                        associated_siabled_extruders.add(extruder_position)
                         break
                 if not skip_group:
                     filtered_object_groups.append(group)
 
+            if has_model_with_disabled_extruders:
+                self.setResult(StartJobResult.ObjectsWithDisabledExtruder)
+                associated_siabled_extruders = [str(c) for c in sorted([int(p) + 1 for p in associated_siabled_extruders])]
+                self.setMessage(", ".join(associated_siabled_extruders))
+                return
+
             # There are cases when there is nothing to slice. This can happen due to one at a time slicing not being
             # able to find a possible sequence or because there are no objects on the build plate (or they are outside
             # the build volume)